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Infectious

Hepatitis C

Also known as: Hepatitis C Virus Infection

Hepatitis C is a viral infection causing liver inflammation that can lead to serious liver damage. Unlike hepatitis B, there is no vaccine, but it is now curable with antiviral treatment.

Understanding Hepatitis C

Approximately 58 million people worldwide have chronic hepatitis C infection. The revolutionary development of direct-acting antivirals (DAAs) has transformed it from a chronic, progressive disease into a curable one.

HCV is primarily transmitted through blood-to-blood contact. Unlike hepatitis B, 55-85% of acute infections become chronic because the immune system often fails to clear the virus.

Modern DAA regimens cure over 95% of chronic HCV infections in just 8-12 weeks, regardless of genotype. The WHO aims for HCV elimination by 2030.

Common Symptoms

People with Hepatitis C often experience the following symptoms.

Silent Chronic Infection

Most people with chronic HCV have no symptoms for decades, only discovered through screening or when liver damage becomes advanced.

Fatigue

The most common reported symptom, often attributed to other causes before HCV diagnosis.

Extrahepatic Manifestations

Cryoglobulinemia, kidney disease, joint pain, and skin conditions can occur before liver symptoms.

Advanced Liver Disease

Jaundice, ascites, easy bruising, and confusion indicate cirrhosis from untreated chronic infection.

Risk Factors

Certain factors may increase your likelihood of developing Hepatitis C.

Injection drug use (past or current)

Blood transfusion before 1992

Born 1945-1965 (baby boomer generation)

Needle stick injuries

Treatment Options

Common approaches to managing hepatitis c. Always consult a healthcare provider for personalized treatment.

Direct-Acting Antivirals

Sofosbuvir/velpatasvir or glecaprevir/pibrentasvir cure >95% of infections in 8-12 weeks with minimal side effects.

Pre-Treatment Assessment

Liver fibrosis staging (FibroScan or biopsy), HCV genotyping, and drug interaction review.

Post-Cure Monitoring

SVR12 (undetectable virus 12 weeks after treatment) confirms cure. Ongoing liver monitoring for those with cirrhosis.

Harm Reduction

For people who inject drugs: needle exchange, opioid substitution therapy, and treatment as prevention.

How It's Diagnosed

Anti-HCV antibody screening test (positive means exposure). HCV RNA confirms active infection. Genotyping guides treatment selection. FibroScan assesses liver fibrosis.

When to See a Doctor

See a doctor for screening if you have any risk factors. Seek care for jaundice, dark urine, persistent fatigue, or right upper abdominal pain.

Prevention Strategies

Steps that may help reduce the risk of developing or worsening hepatitis c.

No vaccine available

Avoid sharing needles or injection equipment

Screen blood products

Universal screening recommended for all adults

Potential Complications

If left untreated or poorly managed, hepatitis c may lead to:

  • Liver cirrhosis (in 15-30% after 20 years)
  • Hepatocellular carcinoma
  • Liver failure requiring transplant
  • Extrahepatic complications

Frequently Asked Questions

Can hepatitis C be completely cured?

Yes. Modern antiviral medications cure over 95% of hepatitis C infections in 8-12 weeks.

Can you get hepatitis C again after being cured?

Yes. Cure does not provide immunity. Reinfection is possible with continued risk behaviour.

Should everyone be tested for hepatitis C?

Yes. The CDC recommends universal HCV screening for all adults at least once in their lifetime.

Related Conditions

Related Symptoms

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

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